Oz Single Cell - Adding spatial context to single-cell sequencing

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Tuesday, September 1, 2020

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11:00 AM AEST - 12:30 PM AEST



About the Webinar

In this episode, we will learn about latest case studies of applying spatial sequencing to study cancer, Covid-19, and tissue biology. We will discuss the complementarity of spatial and single cell sequencing. Is spatial sequencing the “next generation single cell technology”? 

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Professor Itai Yanai – New York University

Itai Yanai is the inaugural director of the Institute for Computational Medicine (ICM) and Professor Biochemistry and Molecular Pharmacology at NYU School of Medicine. Research in the Yanai lab revolves around studying dynamic biological processes through the lens of gene regulation. Using our training as both experimental and computational biologists, we are interested in exploring how gene regulatory pathways are deployed at the molecular level. Members of the lab carry out experiments at the level of individual cells and apply computational approaches to explore the resulting data. In the field of scRNA-Seq, we developed one of the first methods for single-cell RNA-Seq, CEL-Seq and CEL-Seq2. We have also recently proposed an innovative new method called scDual-Seq for studying host-pathogen interactions at the single-cell level. More recently, the lab has also turned to an evo-devo approach to studying tumorigenesis, seeking large-scale principles common to all cancers and their functional relationships.

Dr Arutha Kulasinghe – Queensland University of Technology

Dr Kulasinghe is a NMHRC Research Fellow based at the Translational Research Institute. His research aims to develop biomarkers of response to immunotherapy across a number of solid tumours using spatial analysis of the tumour microenvironment and profiling of liquid biopsy. 

Arti Raghubar – The University of Queensland

Arti Raghubar is a clinical scientist with a special interest in renal cancer and molecular histology. After graduating from Queensland University of Technology with a BAppSci (MedSci) she completed training in a private histology laboratory in Brisbane. She has also completed a MMolBiol (The University of Queensland) investigating micro-proteomics in Immunoglobulin A Nephropathy. She currently works as a clinical scientist at Anatomical Pathology, Pathology Queensland at The Royal Brisbane and Women’s Hospital, and is also undertaking a PhD in renal cancer and the application of multi-omics profiling at the Institute for Molecular Bioscience, The University of Queensland.

Sunny Wu – Garvan Institute of Medical Research 

Sunny is a final year PhD Candidate at the Garvan Institute. His research focuses on unravelling the complexities of the breast tumor microenvironment. In particular, he applies single-cell and spatial transcriptomics technologies to study the cellular heterogeneity of recruited host cells, and their diverse roles in driving tumor progression and immune evasion.


Dr Quan Nguyen – The University of Queensland 

Dr Quan Nguyen is a computational biologist studying cancer complexity at single-cell resolution and in spatial tissue context. He is leading the Genomics and Machine Learning Laboratory at the Institute of Molecular Bioscience, The University of Queensland. The Lab is using spatial sequencing and imaging to quantify cellular dynamics within a tissue section.

Dr Shalin Naik – Walter and Eliza Hall Institute of Medical Research

Dr Shalin Naik is a biologist who uses different single cell technologies to discover how the immune system is generated from stem cells. Shalin heads a Laboratory in the Immunology Division at the Walter and Eliza Hall Institute of Medical Research.


This episode is brought to you by Nanostring and BGI Genomics